This short overview of Pathophysiology could serve mainly as a complementary textbook to international undergraduate students of human medicine in the Czech Republic, especially to those who came to study at Charles University - Faculty of Medicine in Hradec Králové. Although there are many textbooks of Pathophysiology existing in English, the majority of them were written in countries where Pathophysiology does not exist as a separate subject in the curricula of medical schools. Thus, they do not seem to cover fully the scope of Pathophysiology as it is traditionally instructed in the Czech Republic (as well as in some other countries of central Europe).